Regional specificity seen within hypothalamus in neuroimmunomodulation.

ABSTRACT

Wistar strain male albino rats lesioned and sham lesioned at Ventromedial hypothalamus (VMH) were used to study the neuroimmunomodulation by this brain region. Except the decrease in thymus weight/body weight ratio (P < 0.01), and its cellularity (P < 0.02) in immunized VMH lesion animals, the rest of the parameters like plaque forming cells (PFC), antibody titre, leukocyte migration inhibition index, foot pad thickness in the lesioned as well as the lesion immunized animals never deviated from their respective sham and immunized sham animals. Sham operated belongs to VMH when compared to control rats, showed marked decrease in spleen weight (P < 0.001), thymus weight (P < 0.02) and decrease in popliteal lymph node weight (P < 0.001) ratios. After immunization, the immunized sham animals showed a marked decrease in antibody titre (P < 0.05), PFC (P < 0.05), spleen (P < 0.05) and thymus (P < 0.001) weight ratios with the significant increase in splenic cell count (P < 0.01) compared to immunized control rats. VMH may be one of the information receiving center. However, from these results, it is inferred that VMH could not be a modulating center for the many of the parameters studied as far as neuroimmunomodulation is concerned.