Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
Indian J Physiol Pharmacol
;
1990 Oct; 34(4): 252-4
Article
Dans Anglais
| IMSEAR
| ID: sea-108232
ABSTRACT
Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like clonidine, high doses of phentolamine and cimetidine aggravate gastric lesions per se, suggesting that all three may be acting at a common 'receptor' site, possibly the imidazoline-preferring receptor (IPR).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phentolamine
/
Rats
/
Lignées consanguines de rats
/
Ulcère gastrique
/
Mâle
/
Récepteur histaminergique H2
/
Cimétidine
/
Clonidine
/
Récepteurs aux opioïdes
/
Éthanol
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1990
Type:
Article
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