Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 64-8
Article
Dans Anglais
| IMSEAR
| ID: sea-108260
ABSTRACT
The effect of aqueous leaf extract of Azadirachta indica (A. indica) was evaluated in paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aqueous A. indica leaf extract (500 mg/kg, p.o.) significantly (P < 0.01) reduced these elevated levels of AST, ALT and gamma-GT. Paracetamol induced liver necrosis was also found to be reduced as observed macroscopically and histologically.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Plantes médicinales
/
Rats
/
Terpènes
/
Huiles végétales
/
Extraits de plantes
/
Rat Wistar
/
Analgésiques non narcotiques
/
Lésions hépatiques dues aux substances
/
Glycérides
/
Foie
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
2000
Type:
Article
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