Postnatal changes in the brain lipids, glycolipids and gangliosides of rats exposed to arrack/ethanol during gestation and lactation.

ABSTRACT

Effects of exposure of an alcoholic beverage (arrack and its equivalent quantity of alcohol throughout pregnancy and lactation on brain lipids were investigated. Female rats were exposed to arrack (12.00 ml/kg body weigh/day) and ethanol (4.00 g/kg body weight day) before conception and throughout gestation and lactation. For 21 days pups were nursed by their own mothers, afterwards they were fed normal laboratory feed. We found that the level of cholesterol, phospholipids, triacylglycerols, free fatty acids, cerebrosides, ceramide dihexosides, ceramide polyhexosides, sulfatids,, mono and diglycosyl diglycerides and gangliosides were increased in the brain of 21st and 45th day pups. The alterations in the glycolipid profile of the brain persisted even when pups were not directly exposed to alcohol. These alterations in the glycolipid and ganglioside metabolism may be associated with the developmental abnormalities of the brain seen in FAS. The elevation produced in the glycolipid profile of arrack administered pups were more than that caused by its equivalent quantity of ethanol. This suggested an interaction of congeners in the arrack with the alcohol.