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Aggravating action of hydralazine on ethanol-induced gastric lesions.
Indian J Physiol Pharmacol ; 1992 Apr; 36(2): 130-2
Article Dans Anglais | IMSEAR | ID: sea-108449
ABSTRACT
Endogenous nitric oxide has been proposed as one of the mediators of gastric cytoprotection. We studied the effect of the vasodilator hydralazine which acts via nitric oxide and thus is expected to have a gastroprotective action. However, hydralazine aggravates ethanol-induced gastric lesions. This effect is not influenced by pretreatment with the selective alpha 1 adrenergic antagonist prazosin but is abolished by the angiotensin converting enzyme inhibitor, captopril suggesting the involvement of the renin-angiotensin system.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Lignées consanguines de rats / Estomac / Maladies de l'estomac / Mâle / Prazosine / Captopril / Éthanol / Interactions médicamenteuses / Hémorragie gastro-intestinale langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 1992 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Lignées consanguines de rats / Estomac / Maladies de l'estomac / Mâle / Prazosine / Captopril / Éthanol / Interactions médicamenteuses / Hémorragie gastro-intestinale langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 1992 Type: Article