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Neural regulation of glucose homeostasis.
Indian J Physiol Pharmacol ; 1999 Oct; 43(4): 415-24
Article Dans Anglais | IMSEAR | ID: sea-108478
ABSTRACT
The regulation of blood glucose is generally stated to be under the control of the endocrine system. But the endocrine secretion is itself regulated by the central nervous system, especially the hypothalamus. The brain can sense the energy status of the body by using neural afferent signals and metabolic cues such as glucose. A variety of experimental evidences have been put forth to support the postulate that there are "glucoreceptors", sensitive to blood glucose and glucose utilization, in the hypothalamus. Gastrointestinal afferents, which carry information about the energy intake, reach the hypothalamic regions and interact with the glucose sensitive mechanisms. Available evidence suggests that obesity and decreased body weight, resulting from lesions of the hypothalamic 'satiety' and 'feeding' centres respectively, are not only due to altered food intake, but also to derangement in glucose homeostasis. The medial preoptic area does the fine tuning of energy balance (regulation of food intake) in response to alterations in the temperature, locomotor activity and sleep wakefulness. Thus the hypothalamus regulates energy balance through its control of energy intake on the one hand, and its expenditure and storage on the other. Neuroendocrine system and autonomic nervous system deal with storage and expenditure of energy.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Système nerveux autonome / Glycémie / Encéphale / Tronc cérébral / Humains / Transduction du signal / Consommation alimentaire / Métabolisme énergétique / Homéostasie / Hypothalamus langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 1999 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Système nerveux autonome / Glycémie / Encéphale / Tronc cérébral / Humains / Transduction du signal / Consommation alimentaire / Métabolisme énergétique / Homéostasie / Hypothalamus langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 1999 Type: Article