Effectiveness of N-N-bis-P-chlorophenyl-3p-tolyl glutaric acid diamide (SRC-3605) as a hypocholesterolaemic compound in hypercholesterolaemic female weanling and adult rats.
Indian J Physiol Pharmacol
;
1978 Jul-Sep; 22(3): 279-84
Article
Dans Anglais
| IMSEAR
| ID: sea-108496
ABSTRACT
SRC-3605, N-N-bis-P-chlorophenyl 3-p-tolyl glutaric acid diamide, was studied for its hypocholesterolaemic effect on serum and liver cholesterol in hypercholesterolaemic weanling and adult female rats. Weanlings were administered doses of SRC-3605 ranging from 100 to 300 mg/kg body weight for 4 or 8 consecutive days. The greatest hypocholesterolaemic effect was observed with doses of 150, 200 and 250 mg, although a progressive decreases in serum cholesterol was noted with increasing doses. Hepatic cholesterol decreases supported the serum data, but were inconsistent. Hypercholesterolaemic adult animals received 50, 100, 150 or 200 mg/kg body weight of either SRC-3605 or clofibrinic acid for 4 days. A decrease in serum cholesterol levels was observed only with the 200 mg SRC-3605. No clear-cut influence of the either compounds was found on hepatic cholesterol. The results indicated that SRC-3605 possesses the property to reduce both serum and liver cholesterol in hypocholesterolaemic weanling female rats.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Femelle
/
Cholestérol
/
Clofibrate
/
Glutarates
/
Hypercholestérolémie
/
Foie
/
Animaux
/
Animaux allaités
/
Anticholestérolémiants
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1978
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS