Serum phenytoin levels with different brands.
Indian J Physiol Pharmacol
;
1986 Apr-Jun; 30(2): 171-6
Article
Dans Anglais
| IMSEAR
| ID: sea-108540
ABSTRACT
Four brands of phenytoin were studied in 60 newly diagnosed epileptic patients randomly and equally placed in 4 groups. Serum phenytoin levels were estimated by EMIT and spectrophotometric methods both of which gave close values with good correlation (r = 0.985). Average serum levels and the incidence of remission achieved with the 4 brands varied within statistical scatter; thus these 4 brands manifested equivalent therapeutic efficacy. In 22 patients serum level was less than 5 micrograms/ml, in 9 of whom attacks remained uncontrolled. In 38 patients serum level exceeded 5 micrograms/ml in 2 of whom attacks were uncontrolled. In 44 out of 60 patients the 2 weeks serum levels were significantly higher (P less than 0.001 by paired t-test) than those after 3 months. In the remaining 16 patients the serum levels at 3 months were significantly higher than at 2 weeks levels (P less than 0.01).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénytoïne
/
Spectrophotométrie
/
Femelle
/
Humains
/
Mâle
/
Biodisponibilité
/
Répartition aléatoire
/
Techniques immunoenzymatiques
/
Adulte
/
Épilepsie
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1986
Type:
Article
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