Studies on rectal temperature of rats in relation to seasonal air temperature and morphine administration.
Indian J Physiol Pharmacol
;
1980 Jul-Sep; 24(3): 205-15
Article
Dans Anglais
| IMSEAR
| ID: sea-108593
ABSTRACT
The present findings demonstrate that seasonal air temperature does not only influence the basal core temperature of rats, but also modifies the physiological/pharmacological actions of drugs. Thus, at low ambient temperature, intracerebroventricular on intraperitoneal administration of morphine produces mainly hypothermia followed by a secondary rise in rectal temperature. On the other hand, at high ambient temperature, the drug produces hyperthermia only. The hypothermic response at low ambient temperature is abolished by pretreatment of rats with 6-hydroxydopamine but not with phenoxybenzamine administration. This suggests that catecholamine pathway in the central nervous system is involved in morphine induced hypothermic response. Further, the role of cholinergic neurons in such response is also indicated.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénoxybenzamine
/
Rats
/
Saisons
/
Température
/
Température du corps
/
Mâle
/
Hémicholinium-3
/
Hydroxydopamines
/
Injections péritoneales
/
Injections ventriculaires
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1980
Type:
Article
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