Effect of nimodipine on male reproductive functions in rats.
Indian J Physiol Pharmacol
;
2000 Oct; 44(4): 449-55
Article
Dans Anglais
| IMSEAR
| ID: sea-108734
ABSTRACT
Nimodipine, a dihydropyridine calcium channel blocker, was administered orally using two different doses (40 mg and 60 mg/kg/day) to rats. Both short term (2 weeks) and long term (6 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and acrozomal reaction. Zona-pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Nimodipine stimulated Ca2+ ATPase activity in isolated plasma membrane of rate spermatozoa. In conclusion, short term and long term administration of nimodipine has deleterious effect on male reproductive functions in rats.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Reproduction
/
Numération des spermatozoïdes
/
Mobilité des spermatozoïdes
/
Zone pellucide
/
Femelle
/
Mâle
/
Inhibiteurs des canaux calciques
/
Nimodipine
/
Calcium-Transporting ATPases
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
2000
Type:
Article
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