Vascular desensitisation--possible role of prostaglandins.
Indian J Physiol Pharmacol
;
1987 Jan-Mar; 31(1): 42-50
Article
Dans Anglais
| IMSEAR
| ID: sea-108970
ABSTRACT
Prolonged exposure to noradrenaline (NA) brings about an increase in the release of prostaglandin (PG)-like material from rat aortic strip. The release is greater with oxymetazoline while methoxamine decreases it. These effects are blocked by yohimbine and prazosin respectively. Pretreatment with 6-OHDA or reserpine diminishes the release of PG-like material. Barium chloride, a non-specific spasmogen, does not affect the release significantly. It appears therefore that the source of PG-like material is presynaptic and that its release mechanism is linked to an alpha 2 (alpha 2) adrenoceptor. It is proposed that this release of PG-like material contributes to the development of desensitisation in vascular tissue.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Aorte
/
Oxymétazoline
/
Rats
/
Femelle
/
Mâle
/
Résistance aux substances
/
Norépinéphrine
/
Prostaglandines
/
Récepteurs alpha-adrénergiques
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1987
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS