Effect of fatty diet on pharmacokinetics and pharmacodynamics of a liquid theophylline preparation in volunteers.
Indian J Physiol Pharmacol
;
1991 Oct; 35(4): 241-4
Article
Dans Anglais
| IMSEAR
| ID: sea-108975
ABSTRACT
The effect of a standard breakfast and a fatty breakfast on the pharmacokinetics and pharmacodynamics of a theophylline liquid preparation (160 mg-single dose) was examined in 6 healthy, non-smoking male volunteers. The plasma theophylline concentrations after both standard and fatty diet were found to be comparable at each point of time and pharmacokinetic parameters like Cmax, Tmax, T1/2a, T1/2 beta and AUC0-alpha, were also comparable. However, the time taken to attain the therapeutic plasma concentration was earlier and sustained along with the standard breakfast in comparison to that with fatty breakfast. Peak change in PEFR and pulse rate was also observed earlier with the standard diet than with fatty diet. The plasma theophylline concentrations produced after both diets were insufficient to produce any detectable change in subjective symptoms like tremor palpitation, heart burn, nausea, restlessness and tenseness. However, theophylline after fatty breakfast was better tolerated than that after a standard breakfast.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Performance psychomotrice
/
Pouls
/
Valeurs de référence
/
Théophylline
/
Humains
/
Mâle
/
Matières grasses alimentaires
/
Débit expiratoire de pointe
/
Adulte
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1991
Type:
Article
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