Evaluation of an intermittent six-month regimen in new pulmonary tuberculosis patients with diabetes mellitus.
Article
Dans Anglais
| IMSEAR
| ID: sea-110505
ABSTRACT
BACKGROUND:
The treatment of tuberculosis (TB) with category I regimen of the Revised National Tuberculosis Control Programme (RNTCP) for patients with diabetes mellitus (DM) needs evaluation.OBJECTIVE:
To assess the cure and relapse rates in 3 years, among the new smear-positive TB patients with Type-2 DM (DMTB) treated with CAT-I regimen (2E3H3R3Z3/4R3H3) of RNTCP.METHODOLOGY:
TB suspects attending the diabetology units and the TB research centre (TRC) Chennai, were investigated. Eligible DMTB cases were enrolled. Baseline estimation of cardiac, renal, liver function tests and glycosylated-HBA1c were undertaken. All patients received 2E3H3R3Z3/4R3H3 under supervision at TRC. Clinical and sputum (smear and culture) examinations and monitoring of diabetic status were undertaken every month up to 24 months, then once in 3 months up to 36 months.RESULTS:
Of 100 patients admitted, 7 were excluded for various reasons from analysis. Of 93 patients, 87 (94%) had a favourable response at the end of treatment. Pre and post treatment mean glycosylated-HBA1c were 9.7% and 8.4% (>7% poor control). During follow-up period, 6 died and one lost to follow-up. Of the remaining, four relapsed.CONCLUSION:
Category-I regimen, recommended for all the new smear-positive patients in the Indian TB programme, is effective in the treatment of DMTB patients, despite poor control of diabetes.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Récidive
/
Expectoration
/
Facteurs temps
/
Tuberculose pulmonaire
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Études de suivi
/
Résultat thérapeutique
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Année:
2007
Type:
Article
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