Molecular chaperones: the modular evolution of cellular networks.
J Biosci
; 2007 Apr; 32(3): 441-6
Article
de En
| IMSEAR
| ID: sea-110700
Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabilizing the phenotype of various cells and organisms and may serve as potential regulators of evolvability. Chaperones have weak links, connect hubs, are in the overlaps of network modules and may uncouple these modules during stress,which gives an additional protection for the cell at the network-level. Moreover,after stress chaperones are essential to re-build inter-modular contacts by their low affinity sampling of the potential interaction partners in different modules. This opens the way to the chaperone-regulated modular evolution of cellular networks,and helps us to design novel therapeutic and anti-aging strategies.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Transduction du signal
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Régulation de l'expression des gènes
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Mort cellulaire
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Chaperons moléculaires
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Isoformes de protéines
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Évolution biologique
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Protéines du choc thermique
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Modèles biologiques
langue:
En
Texte intégral:
J Biosci
Année:
2007
Type:
Article