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Assessment of teratogenecity and embryotoxicity of sludge from textile industries at Pali (India) in Swiss albino mice exposed during organogenetic period.
J Environ Biol ; 2008 Nov; 29(6): 965-9
Article Dans Anglais | IMSEAR | ID: sea-113184
ABSTRACT
The present investigation was carried out to assess the teratological effects of in-utero exposure of sludge leachate from textile and dyeing industries located in Pali, Rajasthan. Sludge was collected at the combined effluent treatment plant (CETP). Two groups of 10 pregnant Swiss albino mice each, were given sludge leachate of 1/10 and 1/100 dilutions with water ad libitum from 6th day to 15th day of gestation covering the critical period of organogenesis. Cesarean sections were performed on day 18 of gestation and all foetuses were examined for reproductive and teratological tests. Sludge induced maternal toxicity was evidenced by significant increase in leachate consumption, reduction in body weight gain and reduction in fur of the body. Developmental toxicity was evidenced by a significant decrease in foetal weight per litter increase in the number of resorptions and an increase in total number of foetuses showing bone retardation and skeletal variations (specially of skull, sternebrae and vertebrae). The leachate of the sludge that is being dumped in the open areas of the town Pall seems to elicit teratogenic as well as embryotoxic potential as indicated by the findings of the present investigation.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Eaux d'égout / Tératogènes / Industrie textile / Malformations dues aux médicaments et aux drogues / Femelle / Grossesse / Tests de toxicité / Exposition maternelle / Organogenèse / Relation dose-effet des médicaments Pays comme sujet: Asie langue: Anglais Texte intégral: J Environ Biol Année: 2008 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Eaux d'égout / Tératogènes / Industrie textile / Malformations dues aux médicaments et aux drogues / Femelle / Grossesse / Tests de toxicité / Exposition maternelle / Organogenèse / Relation dose-effet des médicaments Pays comme sujet: Asie langue: Anglais Texte intégral: J Environ Biol Année: 2008 Type: Article