Responses of serum calcium and inorganic phosphate levels, parathyroid gland and C cells of Rattus norvegicus to heptachlor administration.
J Environ Biol
;
2004 Jan; 25(1): 75-80
Article
Dans Anglais
| IMSEAR
| ID: sea-113186
ABSTRACT
Intramuscular administration of two doses 0.50 LD50 (14.70 mg/kg b w) and 0.75 LD50 (22.30 mg/kg b w) of heptachlor in Rattus norvegicus for 14 days induced significant hypocalcemia without altering serum inorganic phosphate value. Parathyroid chief cells of the experimental rats exhibited degranulation, vacuolation, loss of secretory granules and lipid droplets, reduction in chromatin, and degenerative changes in endoplasmic reticulum and cristae of the mitochondria. Not much of histological and ultrastructural changes could be seen in C cells of the heptachlor treated rats.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Glandes parathyroïdes
/
Phosphates
/
Rats
/
Polluants du sol
/
Mâle
/
Chromatine
/
Calcium
/
Granulations cytoplasmiques
/
Réticulum endoplasmique
/
Appareil de Golgi
langue:
Anglais
Texte intégral:
J Environ Biol
Année:
2004
Type:
Article
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