Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.
J Environ Biol
;
2007 Apr; 28(2): 279-82
Article
Dans Anglais
| IMSEAR
| ID: sea-113879
ABSTRACT
Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Échange de chromatides soeurs
/
Altération de l'ADN
/
Masoprocol
/
Femelle
/
Humains
/
Lymphocytes
/
Cellules cultivées
/
Aberrations des chromosomes
/
Contraceptifs oraux synthétiques
/
Agents protecteurs
langue:
Anglais
Texte intégral:
J Environ Biol
Année:
2007
Type:
Article
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