Molecular cloning and characterization of a novel human kinase gene, PDIK1L.
J Genet
;
2003 Apr-Aug; 82(1-2): 27-32
Article
Dans Anglais
| IMSEAR
| ID: sea-114424
ABSTRACT
We isolated a 4301-bp cDNA from a human foetal brain cDNA library by high-throughput cDNA sequencing. It encodes a protein of 341 amino acids, which shows 69% identity with the human kinase CLIK1 (AAL99353), which was suggested to be the CLP-36 interacting kinase. Bioinformatics analysis suggests that the putative kinase may interact with PDZ and LIM domain proteins. Therefore the protein and its cDNA were named 'PDLIM1 interacting kinase 1 like' (PDIK1L; nomenclature approved by the HUGO Gene Nomenclature Committee). Ensembl Genome Browser located PDIK1L to human chromosome 1p35.3. It spans about 13.7 kb and consists of four exons and three introns. Multiple-tissue cDNA panel PCR revealed that the gene is expressed widely in human tissues liver, kidney, pancreas, spleen, thymus and prostate. The protein appears to be localized to the nucleus.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phosphotransferases
/
Protein kinases
/
Fractions subcellulaires
/
Facteurs de transcription
/
Encéphale
/
Humains
/
Données de séquences moléculaires
/
Protéines nucléaires
/
Séquence nucléotidique
/
Distribution tissulaire
langue:
Anglais
Texte intégral:
J Genet
Année:
2003
Type:
Article
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