Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritis.
J Postgrad Med
;
2004 Oct-Dec; 50(4): 262-5; discussion 266-7
Article
Dans Anglais
| IMSEAR
| ID: sea-115819
ABSTRACT
BACKGROUND AND AIMS:
Recognizing the paucity of data regarding echocardiographic studies of Left ventricular (LV) systolic and diastolic function in patients with juvenile rheumatoid arthritis (JRA), a study was carried out to study these parameters in these subjects. SETTINGS, DESIGN ANDMETHODS:
Thirty-five patients with JRA and an equal number of age- and sex-matched controls were studied by two-dimensional and Doppler echocardiography.RESULTS:
Patients with JRA had higher systolic and diastolic blood pressures, resting heart rates, LV systolic (26.9+/-4.3 vs. 22.4 +/- 4.1 mm, p=0.001) and diastolic size (42.3+/-4.6 vs. 35.4+/-3.8 mm, p< 0.001) and volumes. Though ejection fraction (EF) and fractional shortening (FS) were normal, they were lower in those with JRA as compared to controls (EF 62.9+/-4.47 vs. 67.5+/-3.63 %, p< 0.001; FS 36.4+/-4.5 vs. 38.5 +/- 6.87, p=0.2). On Doppler analysis the JRA group had lower peak E velocity, higher peak A velocity, higher A VTI and more prolonged IVRT. Male patients had higher A VTI and IVRT as compared to females. Those with longer duration of disease had larger LV systolic (r=0.517, p=0.01) and diastolic dimension (r=0.40, p=0.05) and lower FS (r=-0.506, p=0.01). Patients with polyarticular JRA had higher E and A VTI as compared to those with systemic or oligoarticular types.CONCLUSION:
Despite an asymptomatic cardiac status, significant systolic and diastolic functional abnormalities exist in patients with JRA. The duration of the disease, mode of presentation, patient's age and gender have a significant impact on the left ventricular systolic and diastolic functions in patients with JRA.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Arthrite juvénile
/
Systole
/
Pression sanguine
/
Femelle
/
Humains
/
Mâle
/
Débit cardiaque
/
Études cas-témoins
/
Enfant
/
Fonction ventriculaire gauche
Type d'étude:
Étude observationnelle
langue:
Anglais
Texte intégral:
J Postgrad Med
Année:
2004
Type:
Article
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