Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine.
Indian Pediatr
;
1995 Oct; 32(10): 1077-82
Article
Dans Anglais
| IMSEAR
| ID: sea-11646
ABSTRACT
OBJECTIVE:
Evaluation of immunogenicity and acceptability of PRP-T vaccine among the Indian children.DESIGN:
Multicentric, open, parallel group, comparative study of Haemophilus influenzae type B vaccine, given as single (Group I) or associated (Group II) with DPT vaccine.SETTING:
Five different vaccination clinics.SUBJECTS:
125 children between the age group of 18-24 months. PARAMETERS Measurement of (i) pre and post vaccination antibody titres of Haemophilus influenze type B specific antibody; (ii) Adverse events; and (iii) Tolerance as graded by the physician.RESULTS:
Prevaccination antibody levels were > 0.15 mcg/ml in 56.3% in Group I and 35.7% in Group II. Post-seroconversion was seen in 97% in Group II receiving single and all in Group II (P > 0.05). The vaccine was well tolerated.CONCLUSIONS:
The probability of subclinical infection or cross immunity is high in India. ACTHIB vaccine has a good immunogenicity and tolerance and association with DPT does not modify the immunogenicity of ACTHIB vaccine.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Haemophilus influenzae
/
Vaccination
/
Vaccins anti-Haemophilus
/
Pays en voie de développement
/
Études d'évaluation comme sujet
/
Infections à Haemophilus
/
Inde
Type d'étude:
Essai clinique contrôlé
/
Etude diagnostique
/
Études d'évaluation
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian Pediatr
Année:
1995
Type:
Article
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