Antioxidant vitamin levels in sickle cell disorders.
Article
Dans Anglais
| IMSEAR
| ID: sea-118318
ABSTRACT
BACKGROUND:
Sickle cell disorder is a haemoglobinopathy prevalent in the Vidharbha region of Maharashtra, central India. With recent evidence of oxidative stress in sickle haemoglobinopathy, a possible deficiency of antioxidant vitamins was suspected.METHODS:
We measured plasma vitamin E, vitamin C and beta-carotene levels in persons with heterozygous (n=80) and homozygous sickle cell state (n=20), and suitable healthy controls for these groups (n=100 and 66, respectively) in a community-based study in the villages near our institution.RESULTS:
Subjects with heterozygous sickle cell trait had lower vitamin E levels than their respective controls (p < 0.05). Subjects with homozygous sickle cell disease had lower levels of all three vitamins (p < 0.05). Vitamins E and C levels showed a significant positive correlation in both forms of sickle cell disorder.CONCLUSION:
Our findings suggest that there is depletion of the antioxidant vitamins, particularly in severe forms of sickle cell disorder. A trial of administration of therapeutic doses of vitamin E in this condition is warranted.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Acide ascorbique
/
Carence en acide ascorbique
/
Carence en vitamine E
/
Femelle
/
Humains
/
Mâle
/
Études cas-témoins
/
Enfant
/
Facteurs de risque
/
Adolescent
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Année:
2007
Type:
Article
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