Flowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction.
Article
Dans Anglais
| IMSEAR
| ID: sea-118416
ABSTRACT
BACKGROUND:
Following a myocardial infarction, patients are usually started on long term antiplatelet therapy with aspirin in a dose of 80-150 mg/day. However, there are no quick and easy methods to assess the efficacy of the antiplatelet activity of aspirin.METHODS:
We studied 60 consecutive patients (men, < 40 years of age) 8-10 weeks after they had had acute myocardial infarction. These patients were receiving 100 mg aspirin daily orally with or without b-blockers. We measured P-selectin expression and fibrinogen binding by flowcytometry at least 3 times over a period of 2 years in all the patients. We also studied 100 age- and sex-matched controls.RESULTS:
Of the 60 patients, 30 (50%) showed both increased P-selectin and fibrinogen binding by platelets, suggesting platelet activation. Fourteen other patients had increased fibrinogen binding but normal P-selectin expression. Sixteen patients and all the controls had normal results of both tests.CONCLUSION:
Our data show evidence of platelet activation in at least 50% of patients receiving 100 mg of aspirin daily. Flowcytometry for P-selectin expression and fibrinogen binding to platelets can be used to monitor antiplatelet therapy with aspirin following acute myocardial infarction.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Fibrinogène
/
Antiagrégants plaquettaires
/
Études cas-témoins
/
Activation plaquettaire
/
Acide acétylsalicylique
/
Maladie aigüe
/
Études prospectives
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
langue:
Anglais
Année:
2006
Type:
Article
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