Differential association of tumour necrosis factor-alpha single nucleotide polymorphism (-308) with tuberculosis and bronchial asthma.
Article
Dans Anglais
| IMSEAR
| ID: sea-118925
ABSTRACT
BACKGROUND:
Tumour necrosis factor (TNF)-alpha is a pleiotropic, pro-inflammatory cytokine of 17 kDa, whose gene is localized on the short arm of chromosome 6. It has a G-308A polymorphism in the promoter region, which is known to be associated with its differential production; the A allele being the high producer. The circulating level of TNF-alpha is under genetic control and implicated in the pathophysiology of asthma and tuberculosis. Since raised levels of TNF-alpha have been found in asthma and tuberculosis, we looked for the association of TNF-alpha G-308A polymorphism in patients with these diseases.METHODS:
A total of 300 blood samples from patients (155 with asthma, 145 tuberculosis) and 211 normal healthy controls were collected. The G-308A polymorphism was studied using amplification refractory mutation system analysis.RESULTS:
The distribution of G/A alleles in the two patient groups when compared with normal controls revealed a statistically significant association with asthma (p = 0.016) but not with tuberculosis (p = 0.178).CONCLUSION:
The data support the common variant common disease hypothesis, which emphasizes that common genetic variations may participate as critical players in inciting common diseases.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Asthme
/
Tuberculose
/
Sujet âgé de 80 ans ou plus
/
Chromosomes humains de la paire 6
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Enfant
/
Enfant d'âge préscolaire
Limites du sujet:
Aged80
langue:
Anglais
Année:
2008
Type:
Article
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