Efficacy of diethylcarbamazine-medicated salt for microfilaraemia of Brugia malayi.
Article
Dans Anglais
| IMSEAR
| ID: sea-119379
ABSTRACT
BACKGROUND:
Pilot studies in India and abroad have demonstrated the benefit of cooking salt fortified with diethylcarbamazine citrate (DEC) for the control of lymphatic filariasis. In India, DEC-medicated salt has been introduced on a commercial basis in the Cherthala region of Kerala, which is endemic for Brugia malayi (B. malayi). We studied the efficacy of DEC-medicated salt in the clearance of microfilaraemia of B. malayi.METHODS:
Eighteen cases of microfilaraemia (11 men; 7 women) were selected; 14 in the experimental group (i.e. treated with 0.2% w/w DEC-medicated salt) and the rest as the control group who were given a placebo. The consumption of salt and the status of parasitaemia were monitored till all the microfilaria carriers became negative.RESULTS:
There was a significant reduction in the density of microfilariae (intensity) among the treated individuals over a period of time. The duration required for the clearance of microfilariae ranged from 9 to 30 [mean (SD) 19.4 (1.7)] weeks. All microfilaraemics except one reported side-effects which were mild-to-moderate and persisted for a maximum period of one month.CONCLUSION:
DEC-medicated salt effectively clears microfilariae within 30 weeks in parasitaemic individuals. No 'endemic normals' reported any side-effects, though these were common among the microfilaria carriers.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Filariose lymphatique
/
Femelle
/
Humains
/
Mâle
/
Études cas-témoins
/
Méthode des moindres carrés
/
Brugia malayi
/
Chlorure de sodium alimentaire
/
Diéthylcarbamazine
/
Filaricides
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
Pays comme sujet:
Asie
langue:
Anglais
Année:
1997
Type:
Article
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