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Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes.
Neurol India ; 2005 Mar; 53(1): 55-8; discussion 59
Article Dans Anglais | IMSEAR | ID: sea-120139
ABSTRACT
AIMS AND

OBJECTIVES:

To study the clinical and laboratory features of patients admitted with vitamin B12 deficiency-related (B12def) neurological syndromes. SETTINGS AND

DESIGN:

A hospital-based retrospective and prospective study conducted at a referral teaching hospital. MATERIALS AND

METHODS:

Consecutive patients admitted with vitamin B12 deficiency-related neurological disorders during a three-year period from June 2000 to May 2003 were included. Data regarding clinical and laboratory features were obtained. Follow-up was done at least six months following treatment with parenteral vitamin B12. Chi-square test was used for statistical analysis.

RESULTS:

A total of 63 patients (52 males) with a mean age of 46.2 years were studied. The mean duration of symptoms at presentation was 10.3 months. Myeloneuropathy (54%) was the commonest neurological manifestation, followed by myeloneuropathy with cognitive dysfunction (34%), and peripheral neuropathy (9%). Neuropsychiatric manifestations and dementia were observed in 38% and 19% of patients respectively. All the patients had megaloblastic changes in the bone marrow smear. Eleven (17.5%) patients had both hemoglobin and the mean corpuscular volume (MCV) within the normal range. Follow-up after at least six months of therapy with parenteral B12 showed improvement in 54% patients.

CONCLUSIONS:

A high index of suspicion of B12def is required in patients presenting with myelopathy, cognitive decline, or neuropathy. A normal hemoglobin or MCV does not exclude B12def; therefore, other tests such as bone marrow smear and serum vitamin B12 assay are essential, as the condition is often reversible with treatment.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Vitamine B12 / Carence en vitamine B12 / Femelle / Humains / Mâle / Études prospectives / Études rétrospectives / Études de suivi / Troubles de la cognition / Neuropathies périphériques Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Neurol India Année: 2005 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Vitamine B12 / Carence en vitamine B12 / Femelle / Humains / Mâle / Études prospectives / Études rétrospectives / Études de suivi / Troubles de la cognition / Neuropathies périphériques Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Neurol India Année: 2005 Type: Article