Tropical spastic paraparesis in Kerala.
Neurol India
;
2003 Dec; 51(4): 493-6
Article
Dans Anglais
| IMSEAR
| ID: sea-120484
ABSTRACT
Tropical Spastic Paraparesis (TSP) is an uncommon myeloneuropathy with an insular geographic distribution. In 1985, Human T-lymphotropic virus type I (HTLV-1) was reported to be a possible etiological factor. We did an epidemiological, clinical and virological study of 25 cases of TSP. They were predominantly young adult men, whose duration of illness ranged from 6 months to 15 years. Difficulty in walking, stiffness of legs and paraesthesia of legs were the main symptoms. None had tuberculosis, syphilis, malnutrition or lathyrism. Pyramidal signs of the lower limbs, upper limbs, posterior column involvement and spinothalamic tract dysfunction were the common signs. Laboratory findings and cerebrospinal fluid analysis were normal in most. Myelograms or MRI were normal in all. Only 1 case repeatedly tested positive for HTLV-1 antibodies. None of his relatives had clinical or virological evidence of TSP or HTLV-1 infection. Based on our study, we could not link HTLV-I infection to TSP in Indian cases. Virological testing for HTLV-I infection by polymerase chain reaction may be a better tool to reveal such an association. Our cases were similar to seronegative spinal spastic paraplegia. A related new retrovirus or an altered immune response to HTLV-1 due to environmental or dietary factors are possibilities which require further exploration.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Virus T-lymphotrope humain de type 1
/
Paraparésie spastique tropicale
/
Incidence
/
Adolescent
/
Adulte
/
Inde
Type d'étude:
Etude d'incidence
/
Étude pronostique
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Neurol India
Année:
2003
Type:
Article
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