Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach.
Article
Dans Anglais
| IMSEAR
| ID: sea-124347
ABSTRACT
BACKGROUND:
Subsequent to esophagectomy and reconstruction among patients with esophageal cancers, the intrathoracic denervated stomach acts as a passive conduit without peristalsis.OBJECTIVE:
The study was designed to assess the impact of two prokinetic drugs viz. erythromycin and cisapride on the emptying of vagally denervated intrathoracic stomach.METHODS:
Twenty consecutive patients of carcinoma esophagus, who had undergone one stage transhiatal oesophagectomy with cervical esophagogastrostomy and were disease free at three months postoperative follow-up, were included in the study. These patients were randomised into two groups of ten each. The patients in group A received erythromycin, while patients in group B received cisapride. The gastric emptying was studied by scintigraphy, using a standard test meal containing 99m Tc sulphur colloid labelled 'IDLIS' [rice based radio labelled food] before and after the drug treatment.RESULTS:
The pre and post treatment mean gastric half emptying time of the patients in the erythromycin group was 52.6 min and 49.7 min (p > 0.1) and in cisapride group it was 53.76 and 26.4 min respectively (p < 0.05). Intergroup comparison of the difference was not statistically significant.CONCLUSION:
Cisapride is an effective prokinetic agent in the treatment of gastric stasis of the vagally denervated intrathoracic stomach.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Estomac
/
Vagotomie
/
Agents gastro-intestinaux
/
Femelle
/
Humains
/
Mâle
/
Tumeurs de l'oesophage
/
Érythromycine
/
Oesophagectomie
/
Statistique non paramétrique
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Année:
2002
Type:
Article
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