Interrelationship among glomerular filtration rate, fractional sodium excretion and albuminuria in Russell's viper bite patients

ABSTRACT

The interrelationship among Ccr, FENa percent and Ualb were observed in 38 Russell's viper bite patients for 5-days clinical course. Degree of albuminuria had strong hyperbolic relation with glomerular filtration rate (Ccr) on day 1 after bite but not from day 2 onwards. The extent of albuminuria and fractional sodium excretion (FENa per cent) level was found to indicate the severity of renal insult. Albuminuria (Ualb) was associated with impaired Ccr and renal sodium handling. Ccr value below 40 ml/min or albuminuria (Ualb) above 2.07 g/24 hr on day 1 after bite was found in oliguric renal failure patients.