Improved vascular repair is relevant to enhanced renal function with vasodilators in early stage of chronic kidney disease
Dans Anglais
| IMSEAR
| ID: sea-129963
ABSTRACT
Background:
Treatment with vasodilators can improve renal function in early stage of chronic kidney disease (CKD) patients.Objective:
Study the mechanism of vascular repair in 20 CKD patients associated with actual creatinine clearance greater than 60 mL/min/1.73m2 (mean 84+24 mL/min/1.73m2) who had been under treatment with vasodilators.Results:
Initial study on angiogenic factors revealed a low value of VEGF, no significant change in VEGF-R1, whereas antiangiogenic factors showed elevated angiopoietin-2 and no significant change in VEGF-R2. Initial actual creatinine clearance was significantly depleted and fractional excretion of magnesium (FE Mg) was elevated significantly. Follow-up study showed improved VEGF and a significant decline in angiopoietin-2. Such improved vascular repair coincided with enhanced creatinine clearance.Conclusion:
Improved renal function can be achieved by vasodilators under environment favourable for adequate vascular repair.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Année:
2010
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