Glanzmann's thrombasthenia.
Indian Pediatr
;
1992 Jul; 29(7): 837-41
Article
Dans Anglais
| IMSEAR
| ID: sea-13384
ABSTRACT
During January 1981 to June 1991, 20 patients from 16 unrelated families were detected to have Glanzmann's thrombasthenia (GT). Twelve families (75%) had history of consanguinity, with 6 first cousins and 3 uncle-niece marriages; of these 7 were Muslims, 6 Hindus and 3 Christians. There were 12 girls and 8 boys; the mean age at diagnosis was 7.05 +/- 6.03 yr (range 1 day-22 yr). All cases had initial bleeding prior to the age of 5 yr with the mean age at the initial episode of bleeding being 2.21 +/- 1.34 yr (range 1 day-5 yr). Common pattern of bleeding included epistaxis, gingival bleeding, post-traumatic bruises, menorrhagia, gastrointestinal (2 cases), post-operative (2 cases) and spontaneous bleeding (2 cases). No patient showed hemarthrosis, intracranial bleeding or hemoptysis. Menorrhagia was a serious problem necessitating repeated transfusions and hormonal therapy. Twelve cases (60%) required 1-120 units of blood transfusions while five received platelet concentrates.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thrombasthénie
/
Femelle
/
Humains
/
Mâle
/
Nouveau-né
/
Enfant d'âge préscolaire
/
Agrégation plaquettaire
/
Gènes récessifs
/
Hémorragie
/
Nourrisson
langue:
Anglais
Texte intégral:
Indian Pediatr
Année:
1992
Type:
Article
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