Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against β-lactam resistant Staphylococcus aureus.
Indian J Biochem Biophys
;
2010 Feb; 47(1): 53-55
Article
Dans Anglais
| IMSEAR
| ID: sea-135244
ABSTRACT
Antimicrobials derived from plants have been receiving increasing attention in recent years. Antimicrobial activities of a number of phytochemicals have been reported. Many present day antibiotics are ineffective against several pathogenic organisms. About 90% of Staphylococcus aureus isolates from clinical specimens is reported to have resistance against β-lactam antibiotics. In the present study, the effect of hexane, diethyl ether, acetone and water extracts of leaves of a medicinal plant Holoptelea integrifolia has been tested against β-lactam resistant strain of S. aureus in presence of antibiotics such as ampicillin, amoxicillin, cefotaxime and ceftriaxone. The diethyl ether extract has shown the maximum antibacterial activity and the active principle is found to be 1,4-naphthalenedione which is characterized by GC-MS and FTIR spectroscopy. The minimum inhibitory concentration (MIC) of the compound is found to be 4 mg/ml. Structural similarity of this compound with a func- tional group of a β-lactamase-resistant antibiotic indicates that 1,4-naphthlenedione may be acting as an inhibitor to β-lactamase.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Staphylococcus aureus
/
Naphtoquinones
/
Feuilles de plante
/
Ulmaceae
/
Chromatographie gazeuse-spectrométrie de masse
/
Antibactériens
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2010
Type:
Article
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