Preparation and characterization of biopolymeric nanoparticles used in drug delivery.
Indian J Biochem Biophys
;
2010 Feb; 47(1): 56-59
Article
Dans Anglais
| IMSEAR
| ID: sea-135245
ABSTRACT
Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. These include microcapsules, liposomes, polymeric microspheres, microemulsions, polymer micelles, hydrogels, solid nanoparticles etc. In the present study, preparation and characterization of biopolymeric gelatin nanoparticles for encapsulating the antimicrobial drug sulfadiazine and its in vivo drug release in phosphate buffer saline (PBS) have been investigated. The nanoparticles prepared by second desolvation process varied in a size range 200 nm and 600 nm with a drug entrapment efficiency of 50% characterized by atomic force microscopy and dynamic light scattering. The drug release from the nanoparticles occurred up to 30% in a controlled manner.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sulfadiazine
/
Biopolymères
/
Vecteurs de médicaments
/
Systèmes de délivrance de médicaments
/
Microscopie à force atomique
/
Cystéine
/
Nanoparticules
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2010
Type:
Article
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