The complexity of ToxT-dependent transcription in Vibrio cholerae.
Article
Dans Anglais
| IMSEAR
| ID: sea-135372
ABSTRACT
Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Protéines bactériennes
/
Facteurs de transcription
/
Transcription génétique
/
Vibrio cholerae
/
Humains
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Régulation de l'expression des gènes bactériens
/
Choléra
langue:
Anglais
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS