Genetic architecture of HIV-1 genes circulating in north India & their functional implications.
Article
Dans Anglais
| IMSEAR
| ID: sea-137340
ABSTRACT
This review presents data on genetic and functional analysis of some of the HIV-1 genes derived from HIV-1 infected individuals from north India (Delhi, Punjab and Chandigarh). We found evidence of novel B/C recombinants in HIV-1 LTR region showing relatedness to China/Mynmar with 3 copies of Nfκb sites; B/C/D mosaic genomes for HIV-1 Vpr and novel B/C Tat. We reported appearance of a complex recombinant form CRF_02AG of HIV-1 envelope sequences which is predominantly found in Central/Western Africa. Also one Indian HIV-1 envelope subtype C sequence suggested exclusive CXCR4 co-receptor usage. This extensive recombination, which is observed in about 10 per cent HIV-1 infected individuals in the Vpr genes, resulted in remarkably altered functions when compared with prototype subtype B Vpr. The Vpu C was found to be more potent in causing apoptosis when compared with Vpu B when analyzed for subG1 DNA content. The functional implications of these changes as well as in other genes of HIV-1 are discussed in detail with possible implications for subtype-specific pathogenesis highlighted.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Recombinaison génétique
/
Variation génétique
/
Humains
/
Infections à VIH
/
Répétition terminale longue du VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Gènes vpr
/
Produits du gène env du virus de l'immunodéficience humaine
/
Inde
Pays comme sujet:
Asie
langue:
Anglais
Année:
2011
Type:
Article
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