Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran.
Indian J Hum Genet
;
2009 Jan; 15(1): 9-12
Article
Dans Anglais
| IMSEAR
| ID: sea-138863
ABSTRACT
BACKGROUND:
The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins. MATERIALS ANDMETHODs:
We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.RESULT:
None of the analyzed samples revealed deafness-associated mutation.CONCLUSION:
This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
ADN
/
Ethnies
/
Réaction de polymérisation en chaîne
/
Délétion de gène
/
Connexines
/
Arabes
/
Surdité neurosensorielle
/
Iran
/
Mutation
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Hum Genet
Année:
2009
Type:
Article
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