Y-haplotypes and idiopathic male infertility in an Indian population.
Indian J Hum Genet
;
2009 Jan; 15(1): 19-22
Article
Dans Anglais
| IMSEAR
| ID: sea-138865
ABSTRACT
Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Population
/
Chromosome Y
/
Haplotypes
/
Humains
/
Mâle
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Inde
/
Infertilité masculine
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Hum Genet
Année:
2009
Type:
Article
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