Pharmacogenomics of pediatric asthma.
Indian J Hum Genet
;
2010 Sept; 16(3): 111-118
Article
Dans Anglais
| IMSEAR
| ID: sea-138909
ABSTRACT
CONTEXT Asthma is a complex disease with multiple genetic and environmental factors contributing to it. A component of this complexity is a highly variable response to pharmacological therapy. Pharmacogenomics is the study of the role of genetic determinants in the variable response to therapy. A number of examples of possible pharmacogenomic approaches that may prove of value in the management of asthma are discussed below. EVIDENCE ACQUISITION A search of PubMed, Google scholar, E-Medicine, BMJ and Mbase was done using the key words “pharmacogenomics of asthma”, “pharmacogenomics of β-agonist, glucocorticoids, leukotriene modifiers, theophylline, muscarinic antagonists in asthma”. RESULTS:
Presently, there are limited examples of gene polymorphism that can influence response to asthma therapy. Polymorphisms that alter response to asthma therapy include Arg16Gly, Gln27Glu, Thr164Ile for β-agonist receptor, polymorphism of glucocorticoid receptor gene, CRHR1 variants and polymorphism of LTC4S, ALOX5. Polymorphic variants of muscarinic receptors, PDE4 and CYP450 gene variants.CONCLUSION:
It was concluded that genetic variation can improve the response to asthma therapy. However, no gene polymorphism has been associated with consistent results in different populations. Therefore, asthma pharmacogenomic studies in different populations with a large number of subjects are required to make possible tailoring the asthma therapy according to the genetic characteristic of individual patient.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Périodiques comme sujet
/
Asthme
/
Humains
/
Enfant d'âge préscolaire
/
Bases de données bibliographiques
/
Bases de données factuelles
/
PubMed
/
Exposition environnementale
/
/
Inde
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Hum Genet
Année:
2010
Type:
Article
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