Acute promyelocytic leukemia with unusual karyotype.
Indian J Hum Genet
;
2011 Sept; 17(3): 235-237
Article
Dans Anglais
| IMSEAR
| ID: sea-138970
ABSTRACT
Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Leucémie aiguë promyélocytaire
/
Enfant
/
Cytogénétique
/
Caryotype
langue:
Anglais
Texte intégral:
Indian J Hum Genet
Année:
2011
Type:
Article
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