Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta.
Indian J Ophthalmol
;
2012 May; 60(3): 229-231
Article
Dans Anglais
| IMSEAR
| ID: sea-139480
ABSTRACT
A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Ostéogenèse imparfaite
/
Femelle
/
Humains
/
Angiographie fluorescéinique
/
Enfant
/
Études de suivi
/
Évolution de la maladie
/
Néovascularisation choroïdienne
/
Inhibiteurs de l'angiogenèse
/
Facteur de croissance endothéliale vasculaire de type A
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Indian J Ophthalmol
Année:
2012
Type:
Article
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