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Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding.
Article Dans Anglais | IMSEAR | ID: sea-139911
ABSTRACT

Background:

Leukemia is a fatal disease. The oral manifestations of the leukemias occur early in the course of the disease and these oral features can at times act as a diagnostic indicator. Saliva has been used as a diagnostic aid in a number of systemic diseases. Materials and

Methods:

In our study, samples of unstimulated saliva of 30 leukemia patients who were not on chemotherapy were collected and analyzed for salivary amylase and total protein. The oral manifestations and radiographic changes (OPG) were recorded. The correlation between the oral manifestations and the salivary components (salivary amylase and total protein) was assessed for prognostic significance.

Results:

In the present study when the mean values of salivary amylase (1280±754 U/ml) and total protein (647.2±320.7 mg%) were compared with that in control subjects. There was a statistically significant difference for amylase levels (P<.05). On intraoral examination the study subjects showed pallor, gingivitis, gingival enlargement, petechiae, and ecchymosis. On the OPG, the radiographic features included generalized rarefaction of bone (20%), thinning of lamina dura (3.4%), generalized alveolar crest bone resorption (30%), thinning of walls of alveolar crypts (6.7%), besides others, e.g., periapical abscess (10%).

Conclusions:

The saliva of leukemic patients demonstrated obvious changes in composition. A rise in salivary amylase and total protein levels was evident, with the increase in amylase levels being statistically significant.
Sujets)

Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Abcès périapical / Purpura / Salive / Protéines et peptides salivaires / Sujet âgé de 80 ans ou plus / Sujet âgé / Femelle / Humains / Mâle / Radiographie panoramique Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Aged80 langue: Anglais Année: 2010 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Abcès périapical / Purpura / Salive / Protéines et peptides salivaires / Sujet âgé de 80 ans ou plus / Sujet âgé / Femelle / Humains / Mâle / Radiographie panoramique Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Aged80 langue: Anglais Année: 2010 Type: Article