CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern.
Indian J Pathol Microbiol
;
2011 Jan-Mar 54(1): 176-179
Article
Dans Anglais
| IMSEAR
| ID: sea-141949
ABSTRACT
Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocations the usual FISH signal pattern is 1 red-1 yellow fusion signal pattern We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocations t(4;11) (q21;q23),however,with an unusual MLL FISH signal pattern.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Translocation génétique
/
Humains
/
Mâle
/
Leucémie-lymphome lymphoblastique à précurseurs B
/
Hybridation fluorescente in situ
/
Protéine de la leucémie myéloïde-lymphoïde
/
Nourrisson
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Pathol Microbiol
Année:
2011
Type:
Article
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