Creutzfeldt-Jacob disease: An autopsy case report in tertiary care hospital.
Indian J Pathol Microbiol
;
2012 Jan-Mar 55(1): 97-99
Article
Dans Anglais
| IMSEAR
| ID: sea-142187
ABSTRACT
Sporadic Creutzfeldt-Jakob disease (CJD) is the most common prion disease. It is a rare, fatal neurodegenerative disease caused by an infectious protein called prion. The diagnosis can be confirmed only by histological examination of brain tissue. Because of the transmissible nature of the disease, autopsy or brain biopsy cannot be performed at many institutions. Histology shows spongiform changes, neuronal loss, reactive astrocytic proliferation, accumulation of pathologic protein occurring in three general forms Sporadic, familial, and acquired form, including a variant form of CJD. It clinically presents as predominantly progressive dementia with a rapid onset, myoclonus, cerebellar, pyramidal, extra pyramidal and visual signs. Occurrence of periodical spikes in electro-encephalogram, observation of cortical signal alterations in magnetic resonance imaging (MRI) studies, and detection of protein 14-3-3 in cerebrospinal fluid substantiate diagnosis. Autopsy case is presented of a 50 year old woman with progressive dementia, typical neurological symptoms, MRI findings and confirmation of CJD on histology and immunostaining.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Autopsie
/
Noyaux gris centraux
/
Encéphale
/
Femelle
/
Humains
/
Immunohistochimie
/
Maladie de Creutzfeldt-Jakob
/
Issue fatale
/
Centres de soins tertiaires
/
Histocytochimie
langue:
Anglais
Texte intégral:
Indian J Pathol Microbiol
Année:
2012
Type:
Article
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