Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis.
Indian J Pediatr
; 2010 Jan; 77(1): 41-44
Article
de En
| IMSEAR
| ID: sea-142468
Objective. Prevalence and clinical significance of anti-cyclic citrullinated peptide (CCP) antibodies in Indian patients with juvenile idiopathic arthritis (JIA). Methods. Anti-CCP antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 78 patients with JIA which included all 3 major subtypes of the disease: pauciarticular, polyarticular afld systemic onset. Values above 5 relative units were taken as positive. Associations between antiCCP antibodies and clinical and laboratory and radiological parameters were determined. Results. Anti-CCP antibodies were positive in only 2 of 34 (5.9%) patients with pauciarticular JIA and 3 of 17 (17.6%) of systemic,.pnset JIA, whereas it was positive in 13 of 27 (48.1%) of polyarticular JIA patients (p < 0.001). Furthermore, it was seen that among patients with polyarticular JIA, RF-lgM positive patients had higher rate of anti-CCP antibody positivity with 7 of 8 (87.5%) patients having positive anti-CCP antibody (p<0.001). Similarly, patients with erosions (11/19; p<0.001) and deformities (5/-10; p<0.001) were found to have significant association with anti-CCP antibody positivity. Conclusion. Anti-CCP antibodies could be detected more frequently in the sera of JIA patients with severe manifestations like- erosions and deformity. It was also more significantly associated with seropositive polyarticular JIA than other types. It can be presumed from these results that anti-CCP antibodies can be used as a marker to predict severe course of JIA at the onset to guide optimal aggressive therapy.
Mots clés
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Arthrite juvénile
/
Autoanticorps
/
Test ELISA
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Enfant
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Enfant d'âge préscolaire
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Anticorps antinucléaires
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Adolescent
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Citrulline
/
Adulte
Type d'étude:
Prognostic_studies
langue:
En
Texte intégral:
Indian J Pediatr
Année:
2010
Type:
Article