Hepatoblastoma: Experience from a single center.
Indian J Cancer
;
2010 Jul-Sept; 47(3): 314-316
Article
Dans Anglais
| IMSEAR
| ID: sea-144357
ABSTRACT
Background:
The cornerstones of successful treatment of hepatoblastoma (HB) include preoperative chemotherapy followed by complete anatomical resection of tumor, followed by chemotherapy. Advances in chemotherapy in the last 2 decades have been associated with a higher rate of tumor response and possibly a greater potential for resectability.Aims:
We analyzed our single center experience with neoadjuvant chemotherapy (NACT) and surgery in HBs. Settings andDesign:
Our study included all children with HBs who received NACT and underwent surgical excision from January 1997 to July 2004. Materials andMethods:
Patient characteristics, clinical features, clinical course, treatment modalities, and long-term outcome were analyzed.Results:
There were 9 boys and 3 girls, aged 5-60 months (median age at tumor diagnosis was 24 months). All received NACT containing cisplatin and doxorubicin. Of the 12 children, 9 underwent hepatectomy and among them, 4 patients each had right and left hepatectomy and 1 patient underwent right extended hepatectomy. After surgery, all patients completed rest of the chemotherapy course (total 6 cycles). R0 resection was carried out in all the 9 cases with no life-threatening complications.Conclusions:
Our experience of the 9 cases, although less in number, reaffirms the advantages of NACT followed by surgery. The prognosis for patients with resectable tumors is fairly good in combination with chemotherapy.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pronostic
/
Femelle
/
Humains
/
Mâle
/
Protocoles de polychimiothérapie antinéoplasique
/
Doxorubicine
/
Enfant d'âge préscolaire
/
Études de suivi
/
Cisplatine
/
Résultat thérapeutique
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Indian J Cancer
Année:
2010
Type:
Article
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