Spectrum of malignancies among HIV-infected patients in South India.
Indian J Cancer
; 2012 Jan-Mar; 49(1): 176-180
Article
de En
| IMSEAR
| ID: sea-144568
Introduction: The current study examines the spectrum of malignancies among HIV-infected South Indians enrolled in a clinical care program. Materials and Methods: We conducted a nested matched case-control study among 42 HIV-infected cases who developed cancer and 82 HIV-infected controls between 1998 and 2008 at a tertiary care HIV care program in South India. Results: The most common types of cancer included non-Hodgkin's lymphoma (38.1%), Hodgkin's lymphoma (16.7%), squamous cell carcinoma (14.3%), and adenocarcinoma (14.3%). The median duration of time from HIV infection to cancer diagnosis was 549 days [interquartile range (IQR): 58-2013]. The nadir CD4 cell count was significantly lower in cases compared to controls (134 cells/μl vs. 169 cells/μl; P = 0.015). Cancer patients were more likely to have a more advanced HIV disease stage at the time of cancer diagnosis compared to control patients (Stage C: 90.5% vs. 49.4%; P<0.0001). Significantly more cancer patients were receiving antiretroviral treatment relative to control patients at the time of cancer diagnosis (92.9% vs. 66.3%; P=0.001). Conclusions: HIV-infected patients who developed cancer had more advanced immunodeficiency at the time of cancer diagnosis and a lower nadir CD4 cell count. It is possible that with the continued roll-out of highly active antiretroviral therapy in India, the incidence of HIV-associated malignancies will decrease.
Mots clés
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Lymphome malin non hodgkinien
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Femelle
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Humains
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Maladie de Hodgkin
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Carcinome épidermoïde
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Adénocarcinome
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Études cas-témoins
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Infections à VIH
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Numération des lymphocytes CD4
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Adulte
Type d'étude:
Observational_studies
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Risk_factors_studies
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Indian J Cancer
Année:
2012
Type:
Article