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Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy.
Indian J Med Sci ; 2009 June; 63(6) 244-252
Article Dans Anglais | IMSEAR | ID: sea-145414
ABSTRACT

Background:

Office hysteroscopy with endometrial biopsy is usually the first investigation for abnormal uterine bleeding and other uterine diseases.

Aims:

To evaluate the effect of oral drotaverine with mefenamic acid on pain perception during hysteroscopy and endometrial biopsy and to compare it with that of paracervical block using 1% lignocaine and with that of intravenous sedation using diazepam with pentazocine. Settings and

Design:

Outpatient gynecological department and open randomized trial. Materials and

Methods:

One hundred twenty women undergoing hysteroscopy and endometrial biopsy were randomized into 3 groups. Group I received tablet containing drotaverine hydrochloride (80 mg) + mefenamic acid (250 mg), group II received lignocaine paracervically and group III received intravenous diazepam. The intensity of pain during the procedure, 30 and 60 minutes later on visual analog scale (VAS) was assessed. Statistical

Analysis:

Statistical analysis was performed using Kruskal-Wallis test, with the Bonferroni correction, the t test, and the χ2 test.

Results:

Groups were similar in age, parity, vaginal birth or relevant medical history. A statistically significant difference in pain scores was noted among the 3 groups during the procedure (group I, 4.13± 1.28; group II, 5.93± 1.26; group III, 5.58± 1.51), (P< 0.001); as well as 30 minutes later (group I, 1.78± 0.89; group II, 2.53± 0.81; group III, 2.23± 0.94), (P< 0.001) and 60 minutes later (group I, 1.2± 0.46; group II, 1.98± 0.83; group III, 1.68± 0.75), (P< 0.001). VAS at different time intervals among the groups was also statistically significant. No adverse effects were observed.

Conclusions:

Oral drotaverine with mefenamic acid is effective in women undergoing hysteroscopy and endometrial biopsy.
Sujets)

Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Papavérine / Pentazocine / Mesure de la douleur / Femelle / Humains / Hystéroscopie / Acide méfénamique / Résultat thérapeutique / Anesthésiques intraveineux / Adulte Type d'étude: Essai clinique contrôlé langue: Anglais Texte intégral: Indian J Med Sci Année: 2009 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Papavérine / Pentazocine / Mesure de la douleur / Femelle / Humains / Hystéroscopie / Acide méfénamique / Résultat thérapeutique / Anesthésiques intraveineux / Adulte Type d'étude: Essai clinique contrôlé langue: Anglais Texte intégral: Indian J Med Sci Année: 2009 Type: Article