Effect of hemocoagulase for prevention of pulmonary hemorrhage in critical newborns on mechanical ventilation: a randomized controlled trial.
Indian Pediatr
;
2008 Mar; 45(3): 199-202
Article
Dans Anglais
| IMSEAR
| ID: sea-14795
ABSTRACT
OBJECTIVE:
To investigate the role of hemocoagulase to prevent pulmonary hemorrhage in critical newborns on mechanical ventilation.DESIGN:
Randomized controlled trial.SETTING:
Neonatal Intensive Care Unit of an affiliated hospital of a Medical University. CHILDREN Seventy-two critical newborn infants on mechanical ventilation. INTERVENTION The involved neonates were divided randomly into two groups. Forty-one patients were treated with prophylactic hemocoagulase(dripped through the endotracheal tube), and other 31 neonates served as controls. OUTCOMEMEASURES:
Incidence of pulmonary hemorrhage, time of ceasing pulmonary hemorrhage if occurred, time of withdrawing of mechanical ventilation in the survivors, and mortality.RESULTS:
The incidence of pulmonary hemorrhage (12% vs 42%) and the time of ceasing pulmonary hemorrhage (1.36 +/- 0.65 vs 3.58 +/- 0.82, days), were significantly less in infants treated with prophylactic hemocoagulase as compared with the controls (P<0.05). The time to withdrawal of mechanical ventilation was less in the intervention group (3.20 +/- 0.45 vs 5.04 +/- 1.51 days) (P < 0.05). The mortality in children who received hemocoagulase was 22.0%, which was significantly less than controls (41.9 %) (P < 0.05).CONCLUSION:
Prophylactic use of hemocoagulase in mechanically ventilated neonates is effective against pulmonary hemorrhage.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Score d'Apgar
/
Ventilation artificielle
/
Femelle
/
Humains
/
Mâle
/
Nouveau-né
/
Hémostatiques
/
Batroxobine
/
Unités de soins intensifs néonatals
/
Études cas-témoins
Type d'étude:
Essai clinique contrôlé
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Indian Pediatr
Année:
2008
Type:
Article
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