Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast.
Indian J Cancer
;
2013 July-Sept; 50(3): 239-244
Article
Dans Anglais
| IMSEAR
| ID: sea-148655
ABSTRACT
BACKGROUND:
Aim of this study was to investigate the prognostic significance of CD3+ TILs in infiltrating ductal carcinoma (IDC) of the breast. MATERIALS ANDMETHODS:
Immuno-histochemistry was done with CD3 antibodies in tissue sections of 127 breast cancer patients, and CD3+ intra-tumoral and stromal TILs were counted in relation to clinico-pathological variables.RESULTS:
Intra-tumoral and stromal CD3+ TILs were significantly associated with positive lymph node status (P = 0.006, P = 0.043, respectively) without significant association with age, menopausal status, family history, and hormonal status. The higher CD3 intra-tumoral and stromal counts both showed significant association with good prognosis (P = 0.039, P = 0.044, respectively). The intra-tumoral count was higher than stromal count and was independently associated with disease-free survival in stage I and II cancer (P = 0.021).CONCLUSIONS:
CD3+ TILs may serve as independent marker of good prognosis in IDC breast. The findings of this study need further validation on a larger sample size.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pronostic
/
Sujet âgé de 80 ans ou plus
/
Tumeurs du sein
/
Sujet âgé
/
Femelle
/
Humains
/
Immunohistochimie
/
Modèles des risques proportionnels
/
Lymphocytes TIL
/
Antigènes CD3
Type d'étude:
Étude pronostique
Limites du sujet:
Aged80
langue:
Anglais
Texte intégral:
Indian J Cancer
Année:
2013
Type:
Article
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