A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms.

ABSTRACT

A simple, specific, rapid, precise and robust HPLC method has been developed for the quantitation of valsartan in tablet dosage form on a C18 column (250 x 4.6 mm) using a mobile phase consisting of ammonium dihydrogen phosphate buffer methanol (33.566.5) adjusted to pH 3 with formic acid at a flow rate of 1.0 ml/min and detection at 265 nm. The retention time of valsartan was found to be at 11.9 min. The validation of above method was also done. Percentage label claim of the tablet formulations were found to be 100.8%. So the proposed method provides a faster and cost effective quality control tool for routine analysis of valsartan from formulations.