Central nervous system depressant effects of the ethanolic extract of Cymbidium aloifolium (L.).

ABSTRACT

The ethanolic leaf extract of Cymbidium aloifolium (L.) was intended to evaluate the effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract, at the dose of 200 and 400 mg/kg body weight, were shown to have CNS depressant activity by the reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possess CNS depressant activity. The results of statistical analysis showed that the plant extract had significant, (p<0.001) dose dependent, CNS depressant activities when compared to the control.